NRAS, NRAS, Which Mutation Is Fairest of Them All?

J Invest Dermatol. 2016 Oct;136(10):1936-1938. doi: 10.1016/j.jid.2016.06.011.


In 28% of melanomas, NRAS is mutated in one of two hotspots: G12 or Q61. Phosphoproteomic analysis of primary human melanocytes transduced with G12 and Q61 showed different phosphorylation events in the phosphoinositide 3-kinase (PI3K) and mitogen-activated protein kinase (MAPK) pathways. Surprisingly, NRAS(G12) modulates the PI3K pathway and overexpresses the kinase PIM2, whereas NRAS(Q61) is associated with the MAPK pathway and overexpression of CK2α.

Publication types

  • Comment

MeSH terms

  • Humans
  • Melanocytes
  • Melanoma / genetics*
  • Mitogen-Activated Protein Kinases / genetics
  • Mutation
  • Phosphatidylinositol 3-Kinases / genetics*
  • Proto-Oncogene Proteins B-raf / genetics


  • Phosphatidylinositol 3-Kinases
  • Proto-Oncogene Proteins B-raf
  • Mitogen-Activated Protein Kinases