Anxiolytic-like effect of a novel peptide isolated from the venom of the social wasp Synoeca surinama

Flávia M M Gomes; Cássia K Paniago; Daniel O Freire; Adolfo C B Souza; Marcos R Lima; Nelson G Oliveira-Júnior; Octavio L Franco; Márcia R Mortari

doi:10.1016/j.toxicon.2016.09.015

Anxiolytic-like effect of a novel peptide isolated from the venom of the social wasp Synoeca surinama

Toxicon. 2016 Nov:122:39-42. doi: 10.1016/j.toxicon.2016.09.015. Epub 2016 Sep 21.

Authors

Flávia M M Gomes¹, Cássia K Paniago², Daniel O Freire³, Adolfo C B Souza⁴, Marcos R Lima⁵, Nelson G Oliveira-Júnior⁶, Octavio L Franco⁷, Márcia R Mortari⁸

Affiliations

¹ Neuropharmacology Laboratory, Department of Physiological Sciences, Institute of Biological Sciences, University of Brasília, Brasília, Brazil. Electronic address: flaviia.medeiros@hotmail.com.
² Neuropharmacology Laboratory, Department of Physiological Sciences, Institute of Biological Sciences, University of Brasília, Brasília, Brazil. Electronic address: paniago.bio@gmail.com.
³ Neuropharmacology Laboratory, Department of Physiological Sciences, Institute of Biological Sciences, University of Brasília, Brasília, Brazil. Electronic address: daniel.microbiologia@gmail.com.
⁴ Neuropharmacology Laboratory, Department of Physiological Sciences, Institute of Biological Sciences, University of Brasília, Brasília, Brazil. Electronic address: adolfo_quimica@hotmail.com.
⁵ Neuropharmacology Laboratory, Department of Physiological Sciences, Institute of Biological Sciences, University of Brasília, Brasília, Brazil; Evolutionary Ecology Laboratory, Department of Animal and Plant Biology, Biological Sciences Center, State University of Londrina, Londrina, Brazil. Electronic address: robalinho.lima@gmail.com.
⁶ S-Inova Biotech, Post-Graduation on Biotechnology, Dom Bosco Catholic University, Campo Grande, Brazil; Center for Biochemical and Proteomics Analyses, Catholic University of Brasília, Brasília, Brazil. Electronic address: juroyal@gmail.com.
⁷ S-Inova Biotech, Post-Graduation on Biotechnology, Dom Bosco Catholic University, Campo Grande, Brazil; Center for Biochemical and Proteomics Analyses, Catholic University of Brasília, Brasília, Brazil. Electronic address: ocfranco@gmail.com.
⁸ Neuropharmacology Laboratory, Department of Physiological Sciences, Institute of Biological Sciences, University of Brasília, Brasília, Brazil. Electronic address: mmortari@unb.br.

PMID: 27664832
DOI: 10.1016/j.toxicon.2016.09.015

Abstract

Pathological anxiety is among the most common psychiatric illnesses, but current treatment is highly limited. In this study, we investigated the potential anxiolytic-like effects of a peptide isolated from Synoeca surinama venom. Rats treated with this peptide spent more time exploring the open arms of elevated plus maze, which indicates an anxiolytic-like profile for this peptide. This study is the first to show the pharmacological use of S. surinama venom in the treatment of anxiety.

Keywords: Anxiolytic activity; Elevated plus maze; Pathological anxiety; Peptides; Wasp venom.

MeSH terms

Animals
Anti-Anxiety Agents / pharmacology*
Dose-Response Relationship, Drug
Female
Peptides / administration & dosage
Peptides / isolation & purification
Peptides / pharmacology*
Rats
Rats, Wistar
Wasp Venoms / chemistry*

Substances

Anti-Anxiety Agents
Peptides
Wasp Venoms