The effects on plasma L-arginine levels of combined oral L-citrulline and L-arginine supplementation in healthy males

Abstract

We investigated the effects of combining 1 g of l-citrulline and 1 g of l-arginine as oral supplementation on plasma l-arginine levels in healthy males. Oral l-citrulline plus l-arginine supplementation more efficiently increased plasma l-arginine levels than 2 g of l-citrulline or l-arginine, suggesting that oral l-citrulline and l-arginine increase plasma l-arginine levels more effectively in humans when combined.

Keywords: combination effect; l-arginine, l-citrulline, human; oral intake.