The effects on plasma L-arginine levels of combined oral L-citrulline and L-arginine supplementation in healthy males

Biosci Biotechnol Biochem. 2017 Feb;81(2):372-375. doi: 10.1080/09168451.2016.1230007. Epub 2016 Sep 26.


We investigated the effects of combining 1 g of l-citrulline and 1 g of l-arginine as oral supplementation on plasma l-arginine levels in healthy males. Oral l-citrulline plus l-arginine supplementation more efficiently increased plasma l-arginine levels than 2 g of l-citrulline or l-arginine, suggesting that oral l-citrulline and l-arginine increase plasma l-arginine levels more effectively in humans when combined.

Keywords: combination effect; l-arginine, l-citrulline, human; oral intake.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Administration, Oral
  • Adult
  • Arginine / administration & dosage
  • Arginine / blood*
  • Arginine / pharmacology*
  • Citrulline / administration & dosage*
  • Citrulline / pharmacology*
  • Dietary Supplements*
  • Drug Interactions
  • Humans
  • Male
  • Young Adult


  • Citrulline
  • Arginine