Hospitalizations for pulmonary reactions following nitrofurantoin use

S S Jick; H Jick; A M Walker; J R Hunter

doi:10.1378/chest.96.3.512

Hospitalizations for pulmonary reactions following nitrofurantoin use

Chest. 1989 Sep;96(3):512-5. doi: 10.1378/chest.96.3.512.

Authors

S S Jick¹, H Jick, A M Walker, J R Hunter

Affiliation

¹ Boston Collaborative Drug Surveillance Program, Boston University Medical Center, Waltham, MA 02154.

PMID: 2766810
DOI: 10.1378/chest.96.3.512

Abstract

Acute pulmonary illness compatible with previously described nitrofurantoin toxicity and requiring hospitalization occurred three times among 16,101 first courses of therapy with nitrofurantoin. One case of fatal pulmonary fibrosis was ascribed to long-term use of nitrofurantoin among 742 observed recipients of ten or more prescriptions.

Publication types

Case Reports
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Acute Disease
Aged
Drug Hypersensitivity / etiology*
Female
Hospitalization
Humans
Lung Diseases / chemically induced*
Male
Middle Aged
Nitrofurantoin / adverse effects*
Nitrofurantoin / therapeutic use
Pulmonary Fibrosis / chemically induced*

Substances

Nitrofurantoin

Grants and funding

FD-U-000071-07/FD/FDA HHS/United States