Phenotyping, Etiological Factors, and Biomarkers: Toward Precision Medicine in Autism Spectrum Disorders

J Dev Behav Pediatr. 2016 Oct;37(8):659-73. doi: 10.1097/DBP.0000000000000351.


Despite the progress made in understanding the biology of autism spectrum disorder (ASD), effective biological interventions for the core symptoms remain elusive. Because of the etiological heterogeneity of ASD, identification of a "one-size-fits-all" treatment approach will likely continue to be challenging. A meeting was convened at the University of Missouri and the Thompson Center to discuss strategies for stratifying patients with ASD for the purpose of moving toward precision medicine. The "white paper" presented here articulates the challenges involved and provides suggestions for future solutions.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Autism Spectrum Disorder* / classification
  • Autism Spectrum Disorder* / diagnosis
  • Autism Spectrum Disorder* / etiology
  • Autism Spectrum Disorder* / therapy
  • Biomarkers*
  • Congresses as Topic
  • Humans
  • Phenotype*
  • Practice Guidelines as Topic / standards*
  • Precision Medicine / methods
  • Precision Medicine / standards*


  • Biomarkers