Corn oil intake favorably impacts lipoprotein cholesterol, apolipoprotein and lipoprotein particle levels compared with extra-virgin olive oil

Eur J Clin Nutr. 2017 Jan;71(1):33-38. doi: 10.1038/ejcn.2016.169. Epub 2016 Sep 28.


Background: Corn oil (CO) and extra-virgin olive oil (EVOO) are rich sources of unsaturated fatty acids (UFA), but UFA profiles differ among oils, which may affect lipoprotein levels.

Objectives: The objective of this study was to assess the effects of CO versus EVOO intake on fasting lipoprotein and subfraction cholesterol levels, apolipoprotein (apo) A1, apo B, and low-density lipoprotein particle concentrations in men and women.

Subjects/methods: As part of a weight maintenance diet, men and women were provided with food items prepared with 54 g per day of CO or EVOO (21-day treatment, 21-day washout) in a randomized, double-blind, controlled-feeding, crossover trial. Fasting lipoprotein cholesterol and related variables were determined with density gradient ultracentrifugation.

Results: Among the 54 completers, CO reduced total cholesterol, low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C), non-high-density lipoprotein cholesterol (non-HDL-C), apo B and LDL particle concentration to a greater extent compared with EVOO intake. Changes in LDL-C and VLDL-C contributed to the larger reduction in non-HDL-C with CO compared with EVOO intake (-0.39 mmol/l vs -0.04 mmol/l; P<0.001). The larger reduction in LDL-C by CO intake was attributable to changes (P<0.05) caused by CO vs EVOO in large LDL1+2-C (-0.22 mmol/l) and intermediate-density lipoprotein cholesterol (-0.12 mmol/l). HDL-C responses did not differ between treatments, but apo A1 increased more with EVOO compared with CO intake (4.6 versus 0.7 mg/dl, respectively, P=0.016).

Conclusions: CO intake reduced atherogenic lipoprotein cholesterol and particle concentrations to a larger extent than did EVOO, which may have implications for cardiovascular disease risk.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Apolipoprotein A-I / blood
  • Apolipoproteins / blood*
  • Apolipoproteins B / blood
  • Cholesterol / blood*
  • Corn Oil / administration & dosage*
  • Cross-Over Studies
  • Double-Blind Method
  • Eating / physiology*
  • Female
  • Humans
  • Lipoproteins / blood*
  • Lipoproteins, LDL / blood*
  • Male
  • Middle Aged
  • Olive Oil / administration & dosage*


  • APOA1 protein, human
  • Apolipoprotein A-I
  • Apolipoproteins
  • Apolipoproteins B
  • Lipoproteins
  • Lipoproteins, LDL
  • Olive Oil
  • lipoprotein cholesterol
  • Corn Oil
  • Cholesterol