A saltationist theory of cancer evolution

Nat Genet. 2016 Sep 28;48(10):1102-3. doi: 10.1038/ng.3687.


A new study based on single-nucleus sequencing reports that triple-negative breast cancers acquire copy number aberrations in short punctuated bursts in the earliest stages of tumor evolution, rather than continuously and gradually, challenging prevailing models of tumor evolution.

Publication types

  • Comment

MeSH terms

  • DNA Copy Number Variations / genetics*
  • Female
  • Genetic Heterogeneity
  • Humans
  • Selection, Genetic / genetics*
  • Triple Negative Breast Neoplasms / genetics*
  • Triple Negative Breast Neoplasms / pathology