[Clinical effect of compound monoammonium glycyrrhizinate combined with dandelion in treatment of acute paraquat poisoning]

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2016 Jul 20;34(7):535-537. doi: 10.3760/cma.j.issn.1001-9391.2016.07.015.
[Article in Chinese]

Abstract

Objective: To investigate the clinical effect of compound monoammonium glycyrrhizinate combined with dandelion in the treatment of acute paraquat poisoning. Methods: A total of 80 patients with acute paraquat poisoning who were admitted to our hospital were enrolled as study subjects and randomly divided into routine treatment group (38 patients) and traditional Chinese medicine (TCM) group (42 patients) . The patients in the TCM group were given compound monoammonium glycyrrhizinate and dandelion in addition to the treatment in the control group. Serum alanine aminotransferase (ALT) , total bilirubin (TBil) , blood urea nitrogen (BUN) , creatinine (Cr) , and arterial blood lactate (Lac) and partial pressure of oxygen (PaO2) during different time periods on day 3, 7, and 9 of treatment were observed in both groups, and ulceration of oral mucosa, pulmonary fibrosis, multiple organ dysfunction syndrome (MODS) , and mortality were compared between the two groups. Results: On days 3, 7, and 9 of treatment, the routine treatment group had significantly higher serum ALT, TBil, BUN, Cr, and arterial blood Lac than the TCM group. The routine treatment group had significantly lower arterial blood PaO2 than the TCM group, while the TCM group had significantly lower incidence rates of ulceration of oral mucosa, pulmonary fibrosis, and MODS and a significantly lower mortality rate than the routine treatment group (P<0.05) . Conclusion: In the treatment of patients with acute paraquat poisoning, compound monoammonium glycyrrhizinate combined with dandelion can effectively improve organ function, reduce the incidence of pulmonary fibrosis and MODS, improve the healing rate of oral ulcer, improve prognosis, and reduce mortality rate.

Publication types

  • Clinical Trial

MeSH terms

  • Bilirubin
  • Blood Urea Nitrogen
  • Creatinine
  • Glycyrrhizic Acid / therapeutic use*
  • Humans
  • Medicine, Chinese Traditional
  • Multiple Organ Failure
  • Paraquat / poisoning*
  • Plant Extracts / therapeutic use*
  • Poisoning / drug therapy*
  • Prognosis
  • Pulmonary Fibrosis
  • Taraxacum*

Substances

  • Plant Extracts
  • Glycyrrhizic Acid
  • Creatinine
  • Paraquat
  • Bilirubin