Angiotensin I - Converting Enzyme Gene Polymorphism and Activity in Patients with Ischemic Stroke

Sanja Stankovic; Aleksandra Stankovic; Milika Asanin; Zagorka Jovanovic-Markovic; Dragan Alavantic; Nada Majkic-Singh

Angiotensin I - Converting Enzyme Gene Polymorphism and Activity in Patients with Ischemic Stroke

EJIFCC. 2011 Jan 3;21(4):108-17. eCollection 2011 Jan.

Authors

Sanja Stankovic¹, Aleksandra Stankovic², Milika Asanin³, Zagorka Jovanovic-Markovic⁴, Dragan Alavantic², Nada Majkic-Singh¹

Affiliations

¹ Institute of Medical Biochemistry, Clinical Center of Serbia and Faculty of Pharmacy , Belgrade, Serbia.
² "VINCA" Institute of Nuclear Sciences, Laboratory for Radiobiology and Molecular Genetics , Belgrade, Serbia.
³ Institute of Cardiovascular Disease, Clinical Center of Serbia , Belgrade, Serbia.
⁴ Institute of Neurology, Clinical Center of Serbia , Belgrade, Serbia.

PMID: 27683381
PMCID: PMC4975320

Abstract

The possible association of ACE polymorphism with ischemic stroke (IS) was evaluated in 65 patients with IS and 330 age and BMI-matched controls. ACE genotypes were determined by polymerase chain reaction (PCR). There was no significant difference in ACE genotype/allele frequencies between case and control group (p>0.05). Patients with D allele had 4,7 times higher risk for large vessel IS than healthy persons D allele possessors. Persons with D allele had 9.2 times higher risk for large vessel disease than small vessel disease. These data suggest a possible association of ACE gene polymorphism with pathogenesis of large vessel IS.