Adiponectin and pro-inflammatory cytokines are modulated in Vietnamese patients with type 2 diabetes mellitus

J Diabetes Investig. 2017 May;8(3):295-305. doi: 10.1111/jdi.12579. Epub 2016 Oct 30.

Abstract

Aims/introduction: Adipose tissue-derived hormones are associated with metabolic disorders including type 2 diabetes mellitus. The present study investigated the levels of adiponectin and pro-inflammatory cytokines including tumor necrosis factor-α (TNF-α), interleukin-1 beta (IL-1β) and IL-10 in Vietnamese patients with type 2 diabetes mellitus, and their correlations with clinical parameters of overweight and type 2 diabetes mellitus.

Materials and methods: Based on body mass index, 73 patients with type 2 diabetes mellitus were categorized either as overweight or non-overweight. As healthy controls, 57 overweight and non-overweight individuals without type 2 diabetes mellitus were included. The adiponectin, TNF-α, IL-1β and IL-10 levels were measured in the sera samples in all study participants by enzyme-linked immunosorbent assay and were correlated with clinical parameters.

Results: The adiponectin levels were lower in patients with type 2 diabetes mellitus (2.5 ± 1.5 μg/mL) compared with controls (16 ± 18.6 μg/mL; P < 0.0001), and were decreased in overweight individuals compared with those who were not overweight. The TNF-α and IL-1β levels were increased, whereas the IL-10 levels were decreased in patients with type 2 diabetes mellitus and in overweight controls compared with non-overweight controls (P < 0.0001). The adiponectin levels were correlated with the TNF-α, IL-1β, IL-10 levels, and the clinical parameters of overweight and type 2 diabetes mellitus. The quantitative insulin sensitivity check index and homeostasis model assessment insulin resistance indexes were correlated with the relative ratios of adiponectin/TNF-α, adiponectin/IL-1β, adiponectin/IL-10, TNF-α/IL-10 and IL-1β/IL-10.

Conclusions: Adiponectin and pro-inflammatory cytokines are associated with type 2 diabetes mellitus, and might serve as a prognostic marker and a therapeutic intervention for overweight-related type 2 diabetes mellitus.

Keywords: Cytokines; Overweight; Type 2 diabetes mellitus.

MeSH terms

  • Adiponectin / blood*
  • Adult
  • Aged
  • Asian Continental Ancestry Group
  • Biomarkers / blood
  • Cytokines / blood*
  • Diabetes Mellitus, Type 2 / blood*
  • Female
  • Humans
  • Inflammation Mediators / blood*
  • Interleukin-10 / blood
  • Interleukin-1beta / blood
  • Male
  • Middle Aged
  • Tumor Necrosis Factor-alpha / blood
  • Vietnam

Substances

  • ADIPOQ protein, human
  • Adiponectin
  • Biomarkers
  • Cytokines
  • IL10 protein, human
  • Inflammation Mediators
  • Interleukin-1beta
  • Tumor Necrosis Factor-alpha
  • Interleukin-10