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. 2016 Sep 29;13(10):806-7.
doi: 10.1038/nmeth.4000.

DoCM: A Database of Curated Mutations in Cancer

Free PMC article

DoCM: A Database of Curated Mutations in Cancer

Benjamin J Ainscough et al. Nat Methods. .
Free PMC article


Figure 1
Figure 1. DoCM supports existing curation initiatives while occupying a critical niche that balances comprehensiveness and curation burden
DoCM accepts variant batch submission of arbitrary size and varying complexity, allowing the resource to be agile and comprehensive. The DoCM data model limits curation burden, while permitting the entry of genes and variants with high quality functional data. DoCM also aggregates functionally important variants from many other quality resources. CIViC, a knowledgebase of clinical interpretations of variants in cancer (, is focused on summarizing and aggregating evidence of clinically actionable variants into clinical interpretations. ClinVar aggregates structured variant records and clinical assertions, but has largely been focused on germline variants. Variant observation databases, like ICGC, COSMIC, and TCGA, attempt to report the totality of somatic variants observed in patients to-date. All of these databases are complimentary and inform each other.

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