First-in-man observation of Talaromyces marneffei-transmission by organ transplantation

Frederik Hermans; Sien Ombelet; Karlien Degezelle; Dries Testelmans; Dirk E Van Raemdonck; Geert M Verleden; Eric K Verbeken; Pascal Van Bleyenbergh; Katrien Lagrou; Robin Vos

doi:10.1111/myc.12574

First-in-man observation of Talaromyces marneffei-transmission by organ transplantation

Mycoses. 2017 Mar;60(3):213-217. doi: 10.1111/myc.12574. Epub 2016 Sep 30.

Authors

Frederik Hermans¹, Sien Ombelet^{2

3}, Karlien Degezelle⁴, Dries Testelmans¹, Dirk E Van Raemdonck^{5

6}, Geert M Verleden^{1

7}, Eric K Verbeken⁸, Pascal Van Bleyenbergh¹, Katrien Lagrou^{2

3}, Robin Vos^{1

7}

Affiliations

¹ Department of Respiratory Diseases, University Hospitals Leuven, Leuven, Belgium.
² Department of Laboratory Medicine, National Reference Center for Mycosis, University Hospitals Leuven, Leuven, Belgium.
³ Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium.
⁴ Department of Abdominal Transplant Surgery & Transplant Coordination, University Hospitals Leuven, Leuven, Belgium.
⁵ Department of Thoracic Surgery, University Hospitals Leuven, Leuven, Belgium.
⁶ Department of Experimental Thoracic Surgery, KU Leuven, Leuven, Belgium.
⁷ Department of Clinical and Experimental Medicine, Division of Respiratory Diseases, KU Leuven, Leuven, Belgium.
⁸ Department of Histopathology, KU Leuven, Leuven, Belgium.

PMID: 27687582
DOI: 10.1111/myc.12574

Abstract

A lung transplant recipient was diagnosed with penicilliosis due to Talaromyces marneffei, a fungus endemic in South-East Asia, which was acquired by donor transmission. This first case of Talaromyces marneffei-transmission by transplantation underscores that current globalisation of travelling necessitates increased vigilance for transmission of unusual pathogens in organ recipients.

Keywords: emerging disease; fungal infection; infection by mode of transmission; lung transplantation; penicilliosis; zoonotic infection.

Publication types

Case Reports

MeSH terms

Antifungal Agents / therapeutic use
Asia, Southeastern
Humans
Immunocompromised Host
Lung / microbiology*
Lung Transplantation / adverse effects*
Male
Middle Aged
Mycoses / diagnosis
Mycoses / drug therapy
Mycoses / microbiology*
Mycoses / transmission*
Talaromyces / isolation & purification*
Tomography, X-Ray Computed
Travel

Substances

Antifungal Agents