Nucleus or cytoplasm? The mysterious case of SIRT1's subcellular localization

doi:10.1080/15384101.2016.1237170

Comment

. 2016 Dec 16;15(24):3337-3338.

doi: 10.1080/15384101.2016.1237170. Epub 2016 Sep 29.

Nucleus or cytoplasm? The mysterious case of SIRT1's subcellular localization

Wenlong Bai¹, Xiaohong Zhang²

Affiliations

¹ a Department of Pathology and Cell Biology , Morsani College of Medicine, University of South Florida , Tampa , FL , USA.
² b Department of Oncology , Karmanos Cancer Institute , Detroit , MI , USA.

PMID: 27687688
PMCID: PMC5224450
DOI: 10.1080/15384101.2016.1237170

Comment

Nucleus or cytoplasm? The mysterious case of SIRT1's subcellular localization

Wenlong Bai et al. Cell Cycle. 2016.

. 2016 Dec 16;15(24):3337-3338.

doi: 10.1080/15384101.2016.1237170. Epub 2016 Sep 29.

Authors

Wenlong Bai¹, Xiaohong Zhang²

Affiliations

¹ a Department of Pathology and Cell Biology , Morsani College of Medicine, University of South Florida , Tampa , FL , USA.
² b Department of Oncology , Karmanos Cancer Institute , Detroit , MI , USA.

PMID: 27687688
PMCID: PMC5224450
DOI: 10.1080/15384101.2016.1237170

No abstract available

Keywords: SIRT1; fractionation; sirtuins; subcellular localization.

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Macromolecular crowding effect is critical for maintaining SIRT1's nuclear localization in cancer cells.
Sun L, Fang J. Sun L, et al. Cell Cycle. 2016 Oct;15(19):2647-2655. doi: 10.1080/15384101.2016.1211214. Epub 2016 Jul 27. Cell Cycle. 2016. PMID: 27463693 Free PMC article.

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References

1. Imai S, Guarente L. Ten years of NAD-dependent SIR2 family deacetylases: implications for metabolic diseases. Trends Pharmacol Sci 2010; 31:212-20; PMID:20226541; http://dx.doi.org/10.1016/j.tips.2010.02.003 - DOI - PMC - PubMed
1. Imai S, Armstrong CM, Kaeberlein M, Guarente L. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature 2000; 403:795-800; PMID:10693811 - PubMed
1. Deng CX. SIRT1, is it a tumor promoter or tumor suppressor? Int J Biol Sci 2009; 5:147-52; PMID:19173036; http://dx.doi.org/10.7150/ijbs.5.147 - DOI - PMC - PubMed
1. Song NY, Surh YJ. Janus-faced role of SIRT1 in tumorigenesis. Ann N Y Acad Sci 2012; 1271:10-9; http://dx.doi.org/10.1111/j.1749-6632.2012.06762.x - DOI - PMC - PubMed
1. Andersen JL, Thompson JW, Lindblom KR, Johnson ES, Yang CS, Lilley LR, Freel CD, Moseley MA, Kornbluth S. A biotin switch-based proteomics approach identifies 14-3-3zeta as a target of Sirt1 in the metabolic regulation of caspase-2. Mol Cell 2011; 43:834-42; PMID:21884983; http://dx.doi.org/10.1016/j.molcel.2011.07.028 - DOI - PMC - PubMed

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[1] Imai S, Guarente L. Ten years of NAD-dependent SIR2 family deacetylases: implications for metabolic diseases. Trends Pharmacol Sci 2010; 31:212-20; PMID:20226541; http://dx.doi.org/10.1016/j.tips.2010.02.003 - DOI - PMC - PubMed

[2] Imai S, Guarente L. Ten years of NAD-dependent SIR2 family deacetylases: implications for metabolic diseases. Trends Pharmacol Sci 2010; 31:212-20; PMID:20226541; http://dx.doi.org/10.1016/j.tips.2010.02.003 - DOI - PMC - PubMed

[3] Imai S, Armstrong CM, Kaeberlein M, Guarente L. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature 2000; 403:795-800; PMID:10693811 - PubMed

[4] Imai S, Armstrong CM, Kaeberlein M, Guarente L. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature 2000; 403:795-800; PMID:10693811 - PubMed

[5] Deng CX. SIRT1, is it a tumor promoter or tumor suppressor? Int J Biol Sci 2009; 5:147-52; PMID:19173036; http://dx.doi.org/10.7150/ijbs.5.147 - DOI - PMC - PubMed

[6] Deng CX. SIRT1, is it a tumor promoter or tumor suppressor? Int J Biol Sci 2009; 5:147-52; PMID:19173036; http://dx.doi.org/10.7150/ijbs.5.147 - DOI - PMC - PubMed

[7] Song NY, Surh YJ. Janus-faced role of SIRT1 in tumorigenesis. Ann N Y Acad Sci 2012; 1271:10-9; http://dx.doi.org/10.1111/j.1749-6632.2012.06762.x - DOI - PMC - PubMed

[8] Song NY, Surh YJ. Janus-faced role of SIRT1 in tumorigenesis. Ann N Y Acad Sci 2012; 1271:10-9; http://dx.doi.org/10.1111/j.1749-6632.2012.06762.x - DOI - PMC - PubMed

[9] Andersen JL, Thompson JW, Lindblom KR, Johnson ES, Yang CS, Lilley LR, Freel CD, Moseley MA, Kornbluth S. A biotin switch-based proteomics approach identifies 14-3-3zeta as a target of Sirt1 in the metabolic regulation of caspase-2. Mol Cell 2011; 43:834-42; PMID:21884983; http://dx.doi.org/10.1016/j.molcel.2011.07.028 - DOI - PMC - PubMed

[10] Andersen JL, Thompson JW, Lindblom KR, Johnson ES, Yang CS, Lilley LR, Freel CD, Moseley MA, Kornbluth S. A biotin switch-based proteomics approach identifies 14-3-3zeta as a target of Sirt1 in the metabolic regulation of caspase-2. Mol Cell 2011; 43:834-42; PMID:21884983; http://dx.doi.org/10.1016/j.molcel.2011.07.028 - DOI - PMC - PubMed

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Nucleus or cytoplasm? The mysterious case of SIRT1's subcellular localization

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Nucleus or cytoplasm? The mysterious case of SIRT1's subcellular localization

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