Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
, 20 (3), 549-555

Effects of Initiating Moderate Wine Intake on Abdominal Adipose Tissue in Adults With Type 2 Diabetes: A 2-year Randomized Controlled Trial

Affiliations
Randomized Controlled Trial

Effects of Initiating Moderate Wine Intake on Abdominal Adipose Tissue in Adults With Type 2 Diabetes: A 2-year Randomized Controlled Trial

Rachel Golan et al. Public Health Nutr.

Abstract

Objective: To generate evidence-based conclusions about the effect of wine consumption on weight gain and abdominal fat accumulation and distribution in patients with type 2 diabetes.

Design: In the 2-year randomized controlled CASCADE (CArdiovaSCulAr Diabetes & Ethanol) trial, patients following a Mediterranean diet were randomly assigned to drink 150 ml of mineral water, white wine or red wine with dinner for 2 years. Visceral adiposity and abdominal fat distribution were measured in a subgroup of sixty-five participants, using abdominal MRI.

Setting: Ben-Gurion University of the Negev, Soroka-Medical Center and the Nuclear Research Center Negev, Israel.

Subjects: Alcohol-abstaining adults with well-controlled type 2 diabetes.

Results: Forty-eight participants (red wine, n 27; mineral water, n 21) who completed a second MRI measurement were included in the 2-year analysis. Similar weight losses (sd) were observed: red wine 1·3 (3·9) kg; water 1·0 (4·2) kg (P=0·8 between groups). Changes (95 % CI) in abdominal adipose-tissue distribution were similar: red wine, visceral adipose tissue (VAT) -3·0 (-8·0, 2·0) %, deep subcutaneous adipose tissue (DSAT) +5·2 (-1·1, 11·6) %, superficial subcutaneous adipose tissue (SSAT) -1·9 (-5·0, 1·2) %; water, VAT -3·2 (-8·9, 2·5) %, DSAT +2·9 (-2·8, 8·6) %, SSAT -0·15 (-3·3, 2·9) %. No changes in antidiabetic medication and no substantial changes in energy intake (+126 (sd 2889) kJ/d (+30·2 (sd 690) kcal/d), P=0·8) were recorded. A 2-year decrease in glycated Hb (β=0·28, P=0·05) was associated with a decrease in VAT.

Conclusions: Moderate wine consumption, as part of a Mediterranean diet, in persons with controlled diabetes did not promote weight gain or abdominal adiposity.

Trial registration: ClinicalTrials.gov NCT00784433.

Keywords: Abdominal adipose tissue; MRI; Mediterranean diet; Type 2 diabetes; Wine.

Similar articles

See all similar articles

Cited by 4 PubMed Central articles

Publication types

Substances

Associated data

Feedback