History-dependent variability in population dynamics during evidence accumulation in cortex

Nat Neurosci. 2016 Dec;19(12):1672-1681. doi: 10.1038/nn.4403. Epub 2016 Oct 3.


We studied how the posterior parietal cortex combines new information with ongoing activity dynamics as mice accumulate evidence during a virtual navigation task. Using new methods to analyze population activity on single trials, we found that activity transitioned rapidly between different sets of active neurons. Each event in a trial, whether an evidence cue or a behavioral choice, caused seconds-long modifications to the probabilities that govern how one activity pattern transitions to the next, forming a short-term memory. A sequence of evidence cues triggered a chain of these modifications resulting in a signal for accumulated evidence. Multiple distinguishable activity patterns were possible for the same accumulated evidence because representations of ongoing events were influenced by previous within- and across-trial events. Therefore, evidence accumulation need not require the explicit competition between groups of neurons, as in winner-take-all models, but could instead emerge implicitly from general dynamical properties that instantiate short-term memory.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Behavior, Animal / physiology*
  • Cerebral Cortex / physiology*
  • Macaca mulatta
  • Male
  • Memory, Short-Term / physiology*
  • Mice, Inbred C57BL
  • Neurons / physiology*
  • Parietal Lobe / physiology
  • Population Dynamics / statistics & numerical data*
  • Saccades