Gastrointestinal histoplasmosis in a patient after autologous stem cell transplant for multiple myeloma

Transpl Infect Dis. 2016 Dec;18(6):939-941. doi: 10.1111/tid.12619. Epub 2016 Nov 10.

Abstract

A 59-year-old patient with multiple myeloma on maintenance chemotherapy presented with fever, weight loss, and night sweats. An F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET) computed tomography (CT) showed intra-abdominal lymphadenopathy with a mesenteric mass that led to further workup and diagnosis of histoplamosis. The patient was treated with amphotericin B and subsequently switched to itraconazole. This exemplifies the usefulness of FDG PET CT in diagnosis of infectious complications.

Keywords: FDG PET CT; Histoplasma; gastrointestinal histoplamosis; histoplasmosis; myeloma; stem cell transplant.

Publication types

  • Case Reports

MeSH terms

  • Amphotericin B / administration & dosage
  • Amphotericin B / therapeutic use
  • Antifungal Agents / administration & dosage
  • Antifungal Agents / therapeutic use
  • Antineoplastic Agents / blood
  • Antineoplastic Agents / therapeutic use
  • Colonoscopy
  • Fever / etiology
  • Fluorodeoxyglucose F18 / administration & dosage
  • Gastrointestinal Diseases / complications
  • Gastrointestinal Diseases / diagnostic imaging*
  • Gastrointestinal Diseases / drug therapy
  • Gastrointestinal Diseases / microbiology
  • Hematopoietic Stem Cell Transplantation / adverse effects*
  • Histoplasma / isolation & purification*
  • Histoplasmosis / complications
  • Histoplasmosis / diagnostic imaging*
  • Histoplasmosis / drug therapy
  • Histoplasmosis / microbiology
  • Humans
  • Ileum / pathology
  • Ileum / surgery
  • Intestinal Obstruction / etiology
  • Intestinal Obstruction / surgery
  • Itraconazole / administration & dosage
  • Itraconazole / therapeutic use
  • Lymphadenopathy / diagnostic imaging
  • Lymphadenopathy / etiology
  • Male
  • Middle Aged
  • Multiple Myeloma / drug therapy
  • Multiple Myeloma / surgery*
  • Positron-Emission Tomography
  • Radiopharmaceuticals / administration & dosage
  • Tomography, X-Ray Computed
  • Weight Loss
  • beta-Glucans / blood

Substances

  • Antifungal Agents
  • Antineoplastic Agents
  • Radiopharmaceuticals
  • beta-Glucans
  • Fluorodeoxyglucose F18
  • Itraconazole
  • Amphotericin B
  • beta-1,3-glucan