Gonadotrope Tumors

Prog Mol Biol Transl Sci. 2016:143:187-210. doi: 10.1016/bs.pmbts.2016.08.005. Epub 2016 Sep 7.


Gonadotrope tumors arise from the gonadotropes of the adenohypophysis. These cells rarely give rise to hyperplasia, usually only in the setting of long-standing premature gonadal failure. In contrast, gonadotrope tumors represent one of the most frequent types of pituitary tumors. Despite their relatively common occurrence, the pathogenesis of gonadotrope tumors remains unknown. Effective nonsurgical therapies remain out of reach. We review the pituitary gonadotrope from the morphologic and functional perspectives to better understand its involvement as the cell of origin of a frequent type of pituitary tumor.

Keywords: adenoma; biochemistry; epidemiology; gonadotrope; immunohistochemistry; morphology; pathogenesis; tumor.

Publication types

  • Review

MeSH terms

  • Animals
  • Biomarkers, Tumor / metabolism
  • Gonadotrophs / pathology*
  • Humans
  • Hyperplasia
  • Neoplasms / diagnostic imaging
  • Neoplasms / epidemiology
  • Neoplasms / pathology*
  • Prognosis


  • Biomarkers, Tumor