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Randomized Controlled Trial
. 2016 Nov;10(11):857-864.e2.
doi: 10.1016/j.jash.2016.08.009. Epub 2016 Sep 7.

The Association Between Self-Reported Medication Adherence Scores and Systolic Blood Pressure Control: A SPRINT Baseline Data Study

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Randomized Controlled Trial

The Association Between Self-Reported Medication Adherence Scores and Systolic Blood Pressure Control: A SPRINT Baseline Data Study

William E Haley et al. J Am Soc Hypertens. .
Free PMC article

Abstract

We examined baseline data from the Systolic Blood Pressure Intervention Trial (SPRINT) to investigate whether medication adherence, measured by the 8-item Morisky Medication Adherence Scale (MMAS-8), was associated with systolic blood pressure (SBP) and whether MMAS-8 score and number of antihypertensive medications interacted in influencing SBP. A total of 8435 SPRINT participants were included: 21.2% had low adherence (MMAS-8: <6); 40.0% had medium adherence (6 to <8); and 38.8% had high adherence (8). SBP was <140 mm Hg in 54.6%; 140-160 mm Hg in 36.6%; and >160 mm Hg in 8.8%. In multivariable regression, medium vs. low adherence weakly associated with lower SBP (odds ratio: 1.17; confidence interval: 1.04, 1.31). SPRINT eligibility criteria should be considered when interpreting results. Efforts to understand and enhance adherence are crucial to improve population health, and using self-report instruments might be considered for predicting treatment adherence and response in future efficacy trials and for identifying patients for adherence support in clinical practice.

Keywords: Clinical trial; MMAS-8; hypertension.

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