HPV Testing of Head and Neck Cancer in Clinical Practice

Recent Results Cancer Res. 2017;206:101-111. doi: 10.1007/978-3-319-43580-0_7.


The pathology laboratory has a central role in providing human papillomavirus (HPV) tests for patients with head and neck cancer. There is an extensive literature around HPV testing and a large number of proprietary HPV tests, which makes the field difficult to navigate. This review provides a concise contemporary overview of the evidence around HPV testing in head and neck cancer and signposts key publications, guideline documents and the most commonly used methods in clinical practice.

Keywords: HPV; Head and neck; Immunohistochemistry; In situ hybridisation; Molecular diagnostics; p16.

Publication types

  • Review

MeSH terms

  • Biomarkers, Tumor / genetics
  • Carcinoma, Squamous Cell / virology*
  • Head and Neck Neoplasms / virology*
  • Humans
  • Molecular Diagnostic Techniques / methods*
  • Papillomaviridae / genetics*
  • Papillomavirus Infections / virology*


  • Biomarkers, Tumor