Abstract
Five new lignan glycosides, wasabisides A-E (1-5), and four known phenolic compounds (6-9), were isolated from the roots of Wasabia japonica. The chemical structures of the new compounds (1-5) were determined through spectroscopic analysis and chemical methods. All isolated compounds (1-9) were evaluated for their potential neuroprotective effects through induction of nerve growth factor in C6 glioma cells, for their effects on nitric oxide levels in lipopolysaccharide-stimulated murine microglia BV2 cells, and for their cytotoxicity against four human tumor cell lines (A549, SK-OV-3, SK-MEL-2, and BT549).
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Antineoplastic Agents, Phytogenic / chemistry
-
Antineoplastic Agents, Phytogenic / isolation & purification*
-
Antineoplastic Agents, Phytogenic / pharmacology
-
Drug Screening Assays, Antitumor
-
Glycosides / chemistry
-
Glycosides / isolation & purification*
-
Glycosides / pharmacology
-
Humans
-
Lignans / chemistry
-
Lignans / isolation & purification*
-
Lignans / pharmacology
-
Lipopolysaccharides / pharmacology
-
Microglia / drug effects
-
Molecular Structure
-
Nitric Oxide / biosynthesis
-
Plant Roots / chemistry*
-
Republic of Korea
-
Wasabia / chemistry*
Substances
-
Antineoplastic Agents, Phytogenic
-
Glycosides
-
Lignans
-
Lipopolysaccharides
-
Nitric Oxide