Brazilian propolis promotes immunomodulation on human cells from American Tegumentar Leishmaniasis patients and healthy donors infected with L. braziliensis

Cell Immunol. 2017 Jan;311:22-27. doi: 10.1016/j.cellimm.2016.09.014. Epub 2016 Sep 29.

Abstract

American Tegumentar Leishmaniasis (ATL) is an infectious disease caused by Leishmania parasites with ineffective treatment. The properties of propolis have been studied in different experimental studies, however, few works have investigated the effects of propolis on human-derived peripheral blood mononuclear cells (PBMC) in leishmaniasis models. Thus, we investigate the immunomodulatory effects of propolis treatment on PBMC from ATL patients and on PBMC from healthy donors infected with Leishmania braziliensis. Our data demonstrate that propolis pretreatment shows immunomodulatory effects on both healthy donors and ATL patients adherent cells, increasing IL-4 and IL-17 and decreasing IL-10, in either the presence or absence of the L. braziliensis infection, demonstrating that propolis contributes with the decrease of the inflammation and could also contribute with parasite control.

Keywords: Human PBMC; IL-10; IL-4; IL-6; In vitro; Th17.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Anti-Inflammatory Agents / therapeutic use*
  • Brazil
  • Cytokines / metabolism
  • Female
  • Humans
  • Immunomodulation
  • Leishmania braziliensis / immunology*
  • Leishmaniasis / immunology*
  • Leukocytes, Mononuclear / drug effects*
  • Leukocytes, Mononuclear / physiology
  • Male
  • Middle Aged
  • Nitric Oxide / metabolism
  • Propolis / therapeutic use*
  • Skin / parasitology
  • Skin / pathology*

Substances

  • Anti-Inflammatory Agents
  • Cytokines
  • Nitric Oxide
  • Propolis