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. 2017 Feb;139(2):708-711.e5.
doi: 10.1016/j.jaci.2016.08.031. Epub 2016 Oct 1.

Human Milk Oligosaccharides and Development of Cow's Milk Allergy in Infants

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Free PMC article

Human Milk Oligosaccharides and Development of Cow's Milk Allergy in Infants

Antti E Seppo et al. J Allergy Clin Immunol. .
Free PMC article

Abstract

Human milk oligosaccharides (HMOs) provide a main substrate to help shape the infant's gut microbiota and affect the maturation of the intestinal mucosal immune system. In our cohort, infants that received human milk with low Lacto-N-fucopentaose (LNFP) III concentrations (< 60μM) were more likely to become affected with cow's milk allergy when compared to high LNFP III-containing milk (odds ratio 6.7, 95% CI 2.0-22).

Figures

Figure 1
Figure 1
Human milk oligosaccharide levels in mothers who have an infant with cow's milk allergy (CMA) and in those with a child without CMA. Non-parametric p-values (Wilcoxon) for the difference in distribution between CMA and non-CMA samples are indicated in each panel. For HMO abbreviations, see Supplementary Table E2.
Figure 2
Figure 2
A correlation heatmap and cluster dendrogram for expression of HMOs. AU (approximately unbiased) p-value for each cluster is shown in the dendrogram. Significant clusters (AU > 95) are labeled (a, b and c). Heatmap of the distance matrix is shown with Spearman correlation values on the lower triangle and the corresponding p-value in the upper triangle. ****≤ 0.001, ***≤0.01, **≤0.05, *≤0.1.

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