AXIN Shapes Tankyrase ARChitecture

Structure. 2016 Oct 4;24(10):1625-1627. doi: 10.1016/j.str.2016.09.003.


The poly(ADP-ribose)polymerase (PARP) Tankyrase uses ankyrin repeat modules to capture substrates via Tankyrase-binding peptide motifs. In this issue of Structure, Eisemann et al. (2016) describe how the signaling protein AXIN can access and conformationally adapt the multivalent ankyrin repeat region of Tankyrase and discuss potential implications for enzymatic substrate modification.

Publication types

  • Comment

MeSH terms

  • Adenosine Diphosphate Ribose
  • Amino Acid Motifs
  • Amino Acid Sequence
  • Ankyrin Repeat
  • Ankyrins
  • Axin Protein*
  • Poly(ADP-ribose) Polymerases / chemistry
  • Tankyrases / chemistry*
  • Telomere


  • Ankyrins
  • Axin Protein
  • Adenosine Diphosphate Ribose
  • Poly(ADP-ribose) Polymerases
  • Tankyrases