Modified Aloe Polysaccharide Restores Chronic Stress-Induced Immunosuppression in Mice

Int J Mol Sci. 2016 Sep 30;17(10):1660. doi: 10.3390/ijms17101660.


Chronic stress generally experienced in our daily lives; is known to augment disease vulnerability by suppressing the host immune system. In the present study; the effect of modified Aloe polysaccharide (MAP) on chronic stress-induced immunosuppression was studied; this Aloe compound was characterized in our earlier study. Mice were orally administered with MAP for 24 days and exposed to electric foot shock (EFS; duration; 3 min; interval; 10 s; intensity; 2 mA) for 17 days. The stress-related immunosuppression and restorative effect of MAP were then analyzed by measuring various immunological parameters. MAP treatment alleviated lymphoid atrophy and body weight loss. The numbers of lymphocyte subsets were significantly normalized in MAP-treated mice. Oral administration of MAP also restored the proliferative activities of lymphocytes; ovalbumin (OVA)-specific T cell proliferation; antibody production; and the cell killing activity of cytotoxic T lymphocytes. In summary; oral administration of MAP ameliorated chronic EFS stress-induced immunosuppression.

Keywords: chronic stress; electric foot shock (EFS); immune restoration; in vivo cytotoxic T lymphocyte (CTL); modified Aloe polysaccharide (MAP).

MeSH terms

  • Administration, Oral
  • Aloe / metabolism*
  • Animals
  • Body Weight / drug effects
  • Immune Tolerance / drug effects*
  • Immunoglobulin G / blood
  • Lymphocyte Activation / drug effects
  • Lymphocyte Subsets / cytology
  • Lymphocyte Subsets / immunology
  • Lymphocyte Subsets / metabolism
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Ovalbumin / immunology
  • Polysaccharides / isolation & purification
  • Polysaccharides / pharmacology*
  • Spleen / cytology
  • Spleen / drug effects
  • Spleen / immunology
  • Stress, Physiological*
  • T-Lymphocytes, Cytotoxic / cytology
  • T-Lymphocytes, Cytotoxic / immunology
  • T-Lymphocytes, Cytotoxic / metabolism


  • Immunoglobulin G
  • Polysaccharides
  • Ovalbumin