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. 2016 Jul 29:10:144-157.
doi: 10.2174/1874613601610010144. eCollection 2016.

Associations and Trends in Cause-Specific Rates of Death Among Persons Reported with HIV Infection, 23 U.S. Jurisdictions, Through 2011

William K Adih  1 , Richard M Selik  1 , H Irene Hall  1 , Aruna Surendera Babu  2 , Ruiguang Song  1
Affiliations

Associations and Trends in Cause-Specific Rates of Death Among Persons Reported with HIV Infection, 23 U.S. Jurisdictions, Through 2011

William K Adih et al. Open AIDS J. .

Abstract

Background: Published death rates for persons with HIV have not distinguished deaths due to HIV from deaths due to other causes. Cause-specific death rates would allow better assessment of care needs.

Methods: Using data reported to the US national HIV surveillance system, we examined a) associations between selected decedent characteristics and causes of death during 2007-2011, b) trends in rates of death due to underlying causes among persons with AIDS during 1990-2011, and among all persons with diagnosed HIV infection (with or without AIDS) during 2000-2011.

Results: During 2007-2011, non-HIV-attributable causes of death with the highest rates per 1,000 person-years were heart disease (2.0), non-AIDS cancers other than lung cancer (1.4), and accidents (0.8). During 1990-2011, among persons with AIDS, the annual rate of death due to HIV-attributable causes decreased by 89% (from 122.0 to 13.2), and the rate due to non-HIV-attributable-causes decreased by 57% (from 20.0 to 8.6), while the percentage of deaths caused by non-HIV-attributable causes increased from 11% to 43%. During 2000-2011, among persons with HIV infection, the rate of death due to HIV-attributable causes decreased by 69% (from 26.4 to 8.3), and the rate due to non-HIV-attributable causes decreased by 28% (from 10.5 to 7.6), while the percentage of deaths caused by non-HIV-attributable causes increased from 25% to 48%.

Conclusion: Among HIV-infected persons, as rates of death due to HIV-attributable causes decreased, rates due to non-HIV-attributable causes also decreased, but the percentages of deaths due to non-HIV-attributable causes, such as heart disease and non-AIDS cancers increased.

Keywords: AIDS; Associations; HIV-attributable causes of death; Non- HIV-attributable causes of death; Rate ratio; Trends; US national HIV surveillance system.

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Figures

Fig. (1)
Fig. (1)
Trends in age-adjusted rates of death due to HIV-attributable and non-HIV-attributable causes among persons with stage 3 classification (AIDS), 23 U.S jurisdictions, 1990-2011.
Fig. (2)
Fig. (2)
Trends in age-adjusted rates of death due to specific non-HIV-attributable causes among persons with stage 3 classification (AIDS), 23 U.S jurisdictions, 1990-2011.
Fig. (3)
Fig. (3)
Trends in age-adjusted rates of death due to underlying causes among persons living with HIV infections, 23 U.S jurisdictions, 2000-2011.
Fig. (4)
Fig. (4)
Trends in rates of death due to HIV-attributable and non-HIV-attributable causes by race/ethnicity, 23 U.S jurisdictions, 2000-2011.
See this image and copyright information in PMC

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