Successful treatment of Acrodermatitis continua of Hallopeau associated with psoriatic arthritis with adalimumab

Eur J Rheumatol. 2015 Jun;2(2):78-79. doi: 10.5152/eurjrheum.2015.0072. Epub 2015 Mar 31.


Acrodermatitis continua of Hallopeau (ACH) is a rare form of pustular psoriasis, mainly affecting distal phalanges of hands and feet. Many therapeutic options exist; however, it tends to be resistant to treatment. We report a 26-year-old man presented with a very severe psoriatic arthritis associated with ACH. Although this patient was resistant to a first line treatment (glucocorticoids and methotrexate), a rapid and dramatic improvement was observed after adalimumab was introduced. The effectiveness and tolerance of the treatment were maintained during the 12-month period of follow-up. This is the first report of the efficacy of adalimumab on ACH in a patient presented with psoriatic arthropathy.

Keywords: Acrodermatitis continua of Hallopeau; adalimumab; psoriatic arthritis.