Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 52 (78), 11701-11703

A Six-Step Total Synthesis of α-Thujone and D 6-α-thujone, Enabling Facile Access to Isotopically Labelled Metabolites

Affiliations

A Six-Step Total Synthesis of α-Thujone and D 6-α-thujone, Enabling Facile Access to Isotopically Labelled Metabolites

Irene Thamm et al. Chem Commun (Camb).

Abstract

The short synthesis of α-thujone relies on the functionalization of the readily available dimethylfulvene. Furthermore, the three main metabolites of the natural product were also synthesized. Since d6-acetone can be used as a starting material, the route developed allows for the facile incorporation of isotopic labels which are required for detecting and quantifying trace amounts via GC/MS analysis.

Similar articles

See all similar articles

Cited by 1 article

LinkOut - more resources

Feedback