Quantitative Systems Pharmacology: A Case for Disease Models

Clin Pharmacol Ther. 2017 Jan;101(1):24-27. doi: 10.1002/cpt.528. Epub 2016 Nov 18.


Quantitative systems pharmacology (QSP) has emerged as an innovative approach in model-informed drug discovery and development, supporting program decisions from exploratory research through late-stage clinical trials. In this commentary, we discuss the unique value of disease-scale "platform" QSP models that are amenable to reuse and repurposing to support diverse clinical decisions in ways distinct from other pharmacometrics strategies.

MeSH terms

  • Biomedical Research / methods
  • Clinical Trials as Topic / methods
  • Decision Making
  • Drug Design*
  • Drug Discovery / methods*
  • Humans
  • Models, Biological*
  • Pharmacology, Clinical / methods
  • Systems Biology / methods*