Gut eradication of VIM-1 producing ST9 Klebsiella oxytoca after fecal microbiota transplantation for diarrhea caused by a Clostridium difficile hypervirulent R027 strain

Diagn Microbiol Infect Dis. 2016 Dec;86(4):470-471. doi: 10.1016/j.diagmicrobio.2016.09.004. Epub 2016 Sep 16.

Abstract

We report the fecal carriage eradication of a VIM-1-producing ST9 Klebsiella oxytoca strain in a pluripathological 84-year-old woman after fecal microbiota transplantation to control relapsing R027 hypervirulent Clostridium difficile infections. The donor was her son, in which the absence of fecal carbapenemase-producing bacteria was corroborated.

Keywords: Carbapenemase eradication; Clostridium difficile infection; Eco-evo strategy; Fecal microbiota transplantation; Multidrug resistant bacteria.

Publication types

  • Case Reports

MeSH terms

  • Carrier State / therapy*
  • Clostridioides difficile / isolation & purification*
  • Diarrhea
  • Enterocolitis, Pseudomembranous / therapy*
  • Fecal Microbiota Transplantation*
  • Female
  • Gastrointestinal Tract / microbiology
  • Humans
  • Klebsiella Infections / therapy*
  • Klebsiella oxytoca / enzymology
  • Klebsiella oxytoca / isolation & purification*
  • beta-Lactamases / metabolism

Substances

  • VIM-1 metallo-beta-lactamase
  • beta-Lactamases