Key elements of metabolomics in the study of biomarkers of diabetes

Diabetologia. 2016 Dec;59(12):2497-2502. doi: 10.1007/s00125-016-4044-y. Epub 2016 Oct 6.

Abstract

Metabolomics is instrumental in the analysis of disease mechanisms and biomarkers of disease. The human metabolome is influenced by genetics and environmental interactions and reveals characteristic signatures of disease. Population studies with metabolomics require special study designs and care needs to be taken with pre-analytics. Gas chromatography coupled to mass spectrometry, liquid chromatography coupled to mass spectrometry or NMR are popular techniques used for metabolomic analyses in human cohorts. Metabolomics has been successfully used in the biomarker search for disease prediction and progression, for analyses of drug action and for the development of companion diagnostics. Several metabolites or metabolite classes identified by metabolomics have gained much attention in the field of diabetes research in the search for early disease detection, differentiation of progressor types and compliance with medication. This review summarises a presentation given at the 'New approaches beyond genetics' symposium at the 2015 annual meeting of the EASD. It is accompanied by another review from this symposium by Bernd Mayer (DOI: 10.1007/s00125-016-4032-2 ) and an overview by the Session Chair, Leif Groop (DOI: 10.1007/s00125-016-4014-4 ).

Keywords: Biomarker; Diabetes; Mass spectrometry; Metabolism; Metabolomics; Nuclear magnetic resonance.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biomarkers / metabolism*
  • Diabetes Mellitus / metabolism*
  • Female
  • Humans
  • Magnetic Resonance Spectroscopy
  • Male
  • Mass Spectrometry
  • Metabolomics / methods*

Substances

  • Biomarkers