Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2016 Oct 3;16(1):1039.
doi: 10.1186/s12889-016-3712-7.

Prevalence of Osteoporosis in China: A Meta-Analysis and Systematic Review

Affiliations
Free PMC article
Review

Prevalence of Osteoporosis in China: A Meta-Analysis and Systematic Review

Peng Chen et al. BMC Public Health. .
Free PMC article

Abstract

Background: We conducted a systematic review and meta-analysis to obtain a reliable estimation of the prevalence of osteoporosis in China and to characterize its epidemiology.

Methods: We identified relevant studies via a search of literature published from 2003 to October 2015 in the PubMed, Web of Science, China National Knowledge Infrastructure, Wanfang and Weipu databases. Both Chinese and WHO criteria were considered acceptable for the diagnosis of osteoporosis. Prevalence estimates were obtained using random effects models. Meta-regression analysis was used to explore the sources of heterogeneity, and publication bias was evaluated by visually inspecting funnel plots.

Results: Overall, 69 articles were included in this study. An obvious increase in the prevalence of osteoporosis was identified over the past 12 years (prevalence of 14.94 % before 2008 and 27.96 % during the period spanning 2012-2015). The prevalence of osteoporosis was higher in females than in males (25.41 % vs. 15.33 %) and increased with age. Osteoporosis prevalence was higher in rural than in urban areas (20.87 % vs. 23.92 %) and higher in southern than in northern areas (23.17 % vs. 20.13 %). At present, the pooled prevalence of osteoporosis in people aged 50 years and older was more than twice the pooled prevalence identified in 2006 (34.65 % vs. 15.7 %). The application of different diagnostic criteria could have an impact on prevalence estimation (19.7 % vs. 29.3 %). Meta-regression suggested that study setting also influenced the estimation of point prevalence (P = 0.022).

Conclusions: The prevalence of osteoporosis in China has increased over the past 12 years, affecting more than one-third of people aged 50 years and older. The prevalence of osteoporosis increased with age and was higher in females than in males. Prevention and control measures have become all the more important given the increase in osteoporosis prevalence, and three-step prevention programmes should be implemented.

Keywords: China; Cross-sectional study; Meta-analysis; Osteoporosis; Prevalence.

Figures

Fig. 1
Fig. 1
Flow diagram of included/excluded studies
Fig. 2
Fig. 2
Forest plot of prevalence of osteoporosis for total people
Fig. 3
Fig. 3
Forest plot of prevalence of osteoporosis for female
Fig. 4
Fig. 4
Forest plot of prevalence of osteoporosis for male
Fig. 5
Fig. 5
Funnel plot for publication bias

Similar articles

See all similar articles

Cited by 33 articles

See all "Cited by" articles

References

    1. Leslie WD, Morin SN. Osteoporosis epidemiology 2013: implications for diagnosis, risk assessment, and treatment. Curr Opin Rheumatol. 2014;26(4):440–6. doi: 10.1097/BOR.0000000000000064. - DOI - PubMed
    1. World Health Organization. Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. Report of a WHO Study Group. World Health Organ Tech Rep Ser. 1994;843:1–129. - PubMed
    1. Cauley JA. Public health impact of osteoporosis. J Gerontol A Biol Sci Med Sci. 2013;68(10):1243–51. doi: 10.1093/gerona/glt093. - DOI - PMC - PubMed
    1. Wade SW, Strader C, Fitzpatrick LA, Anthony MS, O’Malley CD. Estimating prevalence of osteoporosis: examples from industrialized countries. Arch Osteoporos. 2014;9:182. doi: 10.1007/s11657-014-0182-3. - DOI - PubMed
    1. US OOTS . Bone health and osteoporosis: a report of the surgeon general. Rockville: Office of the Surgeon General (US); 2004.
Feedback