Abstract
In this issue, Xue et al. (2016) describe the secondary structure of the heart-specific long non-coding RNA Braveheart, leading to the discovery of a short, asymmetric G-rich loop that controls cardiac lineage commitment by interacting with the transcription factor CNBP.
Copyright © 2016 Elsevier Inc. All rights reserved.
MeSH terms
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Animals
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Base Sequence
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Binding Sites
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Cell Differentiation
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Cell Lineage / genetics
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Gene Deletion
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Gene Expression Regulation
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Humans
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Mice
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Mouse Embryonic Stem Cells / cytology
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Mouse Embryonic Stem Cells / metabolism*
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Myocytes, Cardiac / cytology
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Myocytes, Cardiac / metabolism*
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Nucleic Acid Conformation
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Phenotype
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Protein Binding
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RNA, Long Noncoding / chemistry
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RNA, Long Noncoding / genetics*
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RNA, Long Noncoding / metabolism
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RNA-Binding Proteins / genetics*
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RNA-Binding Proteins / metabolism
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Signal Transduction
Substances
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Cnbp1 protein, mouse
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RNA, Long Noncoding
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RNA-Binding Proteins