lncRNA Structure: Message to the Heart

Mol Cell. 2016 Oct 6;64(1):1-2. doi: 10.1016/j.molcel.2016.09.030.

Abstract

In this issue, Xue et al. (2016) describe the secondary structure of the heart-specific long non-coding RNA Braveheart, leading to the discovery of a short, asymmetric G-rich loop that controls cardiac lineage commitment by interacting with the transcription factor CNBP.

Publication types

  • Comment

MeSH terms

  • Animals
  • Base Sequence
  • Binding Sites
  • Cell Differentiation
  • Cell Lineage / genetics
  • Gene Deletion
  • Gene Expression Regulation
  • Humans
  • Mice
  • Mouse Embryonic Stem Cells / cytology
  • Mouse Embryonic Stem Cells / metabolism*
  • Myocytes, Cardiac / cytology
  • Myocytes, Cardiac / metabolism*
  • Nucleic Acid Conformation
  • Phenotype
  • Protein Binding
  • RNA, Long Noncoding / chemistry
  • RNA, Long Noncoding / genetics*
  • RNA, Long Noncoding / metabolism
  • RNA-Binding Proteins / genetics*
  • RNA-Binding Proteins / metabolism
  • Signal Transduction

Substances

  • Cnbp1 protein, mouse
  • RNA, Long Noncoding
  • RNA-Binding Proteins