The autoimmunity-oral microbiome connection

Oral Dis. 2017 Oct;23(7):828-839. doi: 10.1111/odi.12589. Epub 2016 Nov 24.


To date, there is a major effort in deciphering the role of complex microbial communities, especially the oral and gut microbiomes, in the pathogenesis of various diseases. Increasing evidence indicates a key role for the oral microbiome in autoimmune diseases. In this review article, we discuss links of the oral microbiota to a group of autoimmune diseases, that is, Sjögren's syndrome (SS), systemic lupus erythematosus (SLE), Crohn's disease (CD), and rheumatoid arthritis (RA). We particularly focus on factors that affect the balance between the immune system and the composition of microbiota leading to dysbiosis, loss of tolerance and subsequent autoimmune disease progression and maintenance.

Keywords: Sjögren's syndrome; autoimmunity; crohn's disease; lupus erythematosus; oral microbiome; rheumatoid arthritis.

Publication types

  • Review

MeSH terms

  • Arthritis, Rheumatoid / immunology*
  • Autoimmunity
  • Crohn Disease / immunology*
  • Dysbiosis / immunology
  • Gastrointestinal Microbiome / immunology*
  • Humans
  • Lupus Erythematosus, Systemic / immunology*
  • Mouth / microbiology*
  • Sjogren's Syndrome / immunology*