Contemporary Role of Radiotherapy in the Management of Primary Penile Tumors and Metastatic Disease

Urol Clin North Am. 2016 Nov;43(4):435-448. doi: 10.1016/j.ucl.2016.06.005.


Squamous cell cancer of the penis is a radiocurable malignancy all too often managed solely by partial or total penectomy. Effective management of the primary tumor while preserving penile morphology and function is a priority. External radiotherapy and brachytherapy have a role to play in the definitive management of the primary tumor. Surgical nodal staging remains a cornerstone of management because it is the strongest predictor of survival, and inguinal status determines pelvic management. Postoperative radiotherapy of the regional nodes for high-risk pathology is indicated. Chemoradiotherapy should be considered as neoadjuvant treatment for unresectable nodes or as definitive management.

Keywords: Brachytherapy; Combined chemoradiotherapy; Penile cancer; Penile cancer clinical trials; Postoperative radiotherapy; Radiotherapy; Radiotherapy management of regional lymph nodes; Surface mold radiotherapy.

Publication types

  • Review

MeSH terms

  • Brachytherapy / methods*
  • Carcinoma, Squamous Cell / diagnosis
  • Carcinoma, Squamous Cell / secondary
  • Carcinoma, Squamous Cell / surgery*
  • Combined Modality Therapy
  • Disease Management*
  • Humans
  • Lymph Node Excision
  • Lymphatic Metastasis
  • Male
  • Penile Neoplasms / pathology
  • Penile Neoplasms / radiotherapy*