[Statin associated myopathy in clinical practice. Results of DAMA study]

Clin Investig Arterioscler. 2017 Jan-Feb;29(1):7-12. doi: 10.1016/j.arteri.2016.07.003. Epub 2016 Oct 4.
[Article in Spanish]


Background and objective: Muscle symptoms, with or without elevation of creatin kinase are one of the main adverse effects of statin therapy, a fact that sometimes limits their use. The aim of this study was to evaluate the clinical characteristics of patients treated with statins who have complained muscle symptoms and to identify possible predictive factors.

Patients and methods: A cross-sectional one-visit, non-interventional, national multicenter study including patients of both sexes over 18 years of age referred for past or present muscle symptoms associated with statin therapy was conducted. 3,845 patients were recruited from a one-day record from 2,001 physicians.

Results: Myalgia was present in 78.2% of patients included in the study, myositis in 19.3%, and rhabdomyolysis in 2.5%. Patients reported muscle pain in 77.5% of statin-treated individuals, general weakness 42.7%, and cramps 28.1%. Kidney failure, intense physical exercise, alcohol consumption (>30g/d in men and 20g/d in women) and abdominal obesity were the clinical situations associated with statin myopathy.

Conclusions: Myalgia followed by myositis are the most frequent statin-related side effects. It should be recommended control environmental factors such as intense exercise and alcohol intake as well as abdominal obesity and renal function of the patient treated with statins.

Keywords: Estatinas; Intolerancia a estatinas; Mialgia; Miopatía; Miositis; Muscle symptoms; Myalgia; Myopathy; Myositis; Statin intolerance; Statins; Síntomas musculares.

Publication types

  • Multicenter Study

MeSH terms

  • Aged
  • Alcohol Drinking / adverse effects
  • Creatine Kinase / metabolism
  • Cross-Sectional Studies
  • Exercise / physiology
  • Female
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / administration & dosage
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / adverse effects*
  • Male
  • Middle Aged
  • Muscular Diseases / chemically induced*
  • Muscular Diseases / epidemiology
  • Myalgia / chemically induced*
  • Myalgia / epidemiology
  • Myositis / chemically induced*
  • Myositis / epidemiology
  • Rhabdomyolysis / chemically induced
  • Rhabdomyolysis / epidemiology
  • Risk Factors


  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Creatine Kinase