Resveratrol more effectively than quercetin reduces endothelium degeneration and level of necrosis factor α in patients with coronary artery disease

Wiad Lek. 2016;69(3 pt 2):475-479.


Introduction: endothelial dysfunction (ED) is one of the most important links in the pathogenesis of atherosclerosis (ASVD) - morphological basis of coronary artery disease (CAD).

Objective: to study the effect of polyphenolic antioxidants, resveratrol and quercetin, on endothelial degeneration factors in CAD patients.

Materials and methods: the study involved 93 patients with coronary artery disease: stable angina pectoris, FC II. The cytofluorometric technique was applied to define the level of circulating endothelial microparticles (EMP) CD32+CD40+ in peripheral blood in order to identify ED. The content of tumor necrosis factor α (TNF-α), fibrinogen, hemocoagulation and lipid profile parameters were being determined in the blood, as well. Patients were divided into 3 groups. Basic therapy (β-blockers, statins, aspirin) was prescribed to 33 persons of the comparison group, patients of the study group 1 (30 persons) additionally received resveratrol at a dose of 100 mg daily, patients of the study group 2 (30 persons) got quercetin at a dose of 3 g per day. In 2 months, the second examination of the patients was performed in the amount indicated.

Results: under the influence of resveratrol a significant reduction of the level of TNF-α and the number of EMP in peripheral blood was shown, in contrast to the results of other study groups. All groups showed a decrease in total cholesterol and low-density lipoprotein cholesterol, statistical differences between data of groups were not found. Indicators of coagulogramma in all study groups did not change significantly, however, there was a statistically significant reduction of fibrinogen in the blood.

Conclusions: resveratrol, unlike quercetin, has a positive effect on the endothelial function and systemic inflammation, which may be the result of its influence on intracellular molecular cascades associated with the nuclear transcription factor of NF-kB.

Keywords: circulating endothelial microparticles; coronary artery disease; endothelial dysfunction; quercetin; resveratrol.

MeSH terms

  • Aged
  • Antioxidants / pharmacology
  • Atherosclerosis
  • Coronary Artery Disease / drug therapy*
  • Coronary Artery Disease / pathology
  • Endothelium, Vascular / drug effects*
  • Endothelium, Vascular / pathology
  • Female
  • Fibrinogen / drug effects
  • Humans
  • Inflammation
  • Lipoproteins, LDL / drug effects
  • Male
  • Middle Aged
  • Quercetin / pharmacology*
  • Quercetin / therapeutic use
  • Resveratrol
  • Stilbenes / pharmacology*
  • Stilbenes / therapeutic use
  • Tumor Necrosis Factor-alpha / drug effects


  • Antioxidants
  • Lipoproteins, LDL
  • Stilbenes
  • Tumor Necrosis Factor-alpha
  • Fibrinogen
  • Quercetin
  • Resveratrol