Fine needle aspiration in intraocular metastasis from pleuropulmonary blastoma. A case report and a review of the literature

Diagn Cytopathol. 2017 Feb;45(2):156-160. doi: 10.1002/dc.23618. Epub 2016 Oct 8.

Abstract

Pleuropulmonary blastoma (PPB) is a rare primitive intrathoracic malignant neoplasm that occurs almost exclusively in children and adolescents. PPB is classified into three types according to the presence of cystic and solid areas. We report a case of PPB with an intraocular metastasis diagnosed by fine needle aspiration (FNA): 3-year-old female was treated for type II PPB by neoadjuvant chemotherapy and surgery. Four years later, she presented with an intraocular lesion. To differentiate between metastasis or other malignancy, a transcleral FNA was performed and showed two cellular populations represented by roundish malignant cells and spindle-shaped cells. The patient was treated with chemotherapy and diode laser ablation. A year later, the patient had enucleation and rare residual cells were found on the histological specimen. Patient remains disease-free 66 months after the last surgical treatment. Diagn. Cytopathol. 2017;45:156-160. © 2016 Wiley Periodicals, Inc.

Keywords: fine needle aspiration; metastasis; pleuropulmonary blastoma; transcleral puncture.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Biopsy, Fine-Needle
  • Child, Preschool
  • Eye Neoplasms / pathology*
  • Eye Neoplasms / secondary
  • Female
  • Humans
  • Pulmonary Blastoma / pathology*

Supplementary concepts

  • Pleuropulmonary blastoma