Therapeutic Potential of Phytochemicals in Combination with Drugs for Cardiovascular Disorders

Curr Pharm Des. 2017;23(6):961-966. doi: 10.2174/1381612822666161006145547.


The incidence of cardiovascular disorders is increasing worldwide. Heart disease is the leading cause of death for both men and women. High blood pressure, high low-density lipoprotein cholesterol level, and smoking are key risk factors for heart disease. Other medical conditions such as diabetes, overweight, obesity and lifestyle can put people at a higher risk for coronary heart disease. The preventive measures based on the common drugs may help reduce the risk of cardiovascular diseases. The present review highlights the contributions of therapeutic potential of phytochemicals in management of cardiovascular diseases. However, the delivery efficiency of therapeutic agents can be enhanced in order to improve the efficacy of phytochemicals as a therapeutic agent. The oral administration of phytochemicals as therapeutic agents is a common approach. The review highlights the recent development of natural products for the complementary treatment of cardiovascular diseases. These findings indicate that the combination of therapeutic drugs and natural products may improve the treatment efficacy of therapeutic agents.

Keywords: Natural products; combination therapy; heart diseases; phytochemicals.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Biological Products / administration & dosage
  • Biological Products / chemistry
  • Biological Products / therapeutic use*
  • Cardiovascular Diseases / drug therapy*
  • Humans
  • Phytochemicals / administration & dosage
  • Phytochemicals / chemistry
  • Phytochemicals / therapeutic use*


  • Biological Products
  • Phytochemicals