Nomenclature for renal replacement therapy in acute kidney injury: basic principles

Crit Care. 2016 Oct 10;20(1):318. doi: 10.1186/s13054-016-1489-9.


This article reports the conclusions of a consensus expert conference on the basic principles and nomenclature of renal replacement therapy (RRT) currently utilized to manage acute kidney injury (AKI). This multidisciplinary consensus conference discusses common definitions, components, techniques, and operations of the machines and platforms used to deliver extracorporeal therapies, utilizing a "machine-centric" rather than a "patient-centric" approach. We provide a detailed description of the performance characteristics of membranes, filters, transmembrane transport of solutes and fluid, flows, and methods of measurement of delivered treatment, focusing on continuous renal replacement therapies (CRRT) which are utilized in the management of critically ill patients with AKI. This is a consensus report on nomenclature harmonization for principles of extracorporeal renal replacement therapies. Devices and operations are classified and defined in detail to serve as guidelines for future use of terminology in papers and research.

Keywords: CRRT efficiency; CRRT membranes; CRRT modalities; Clearance; Convection; Diffusion; Dose; Terminology; Transmembrane pressure; Ultrafiltration.

Publication types

  • Review

MeSH terms

  • Acute Kidney Injury / classification*
  • Acute Kidney Injury / therapy*
  • Critical Illness / therapy
  • Humans
  • Renal Dialysis / classification
  • Renal Dialysis / methods
  • Renal Replacement Therapy / classification*
  • Renal Replacement Therapy / methods
  • Terminology as Topic*
  • Ultrafiltration / classification
  • Ultrafiltration / methods