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Clinical Trial
. 2016 Dec;150(6):1242-1250.
doi: 10.1016/j.chest.2016.09.020. Epub 2016 Oct 6.

Association Between Insomnia and Asthma Burden in the Severe Asthma Research Program (SARP) III

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Free PMC article
Clinical Trial

Association Between Insomnia and Asthma Burden in the Severe Asthma Research Program (SARP) III

Faith S Luyster et al. Chest. .
Free PMC article

Abstract

Background: Sleep difficulties are commonly reported by patients with asthma; however, the prevalence of insomnia and its association with disease burden and well-being is unknown. We aimed to determine the prevalence of insomnia, defined as combined sleep-specific complaints with associated daytime symptoms, among a large sample of adults with asthma, and to compare well-being, asthma control, and asthma-related health care utilization in individuals with asthma and insomnia and those without insomnia.

Methods: Baseline data from adults with physician-confirmed asthma enrolled in the Severe Asthma Research Program III was used for analyses (N = 714). Participants completed the Insomnia Severity Index (ISI), Asthma Control Test, Asthma Quality of Life Questionnaire, and Hospital Anxiety and Depression Scale.

Results: Insomnia (ISI ≥ 10) was identified in 263 participants (37%). Presence of insomnia was associated with higher levels of depression and anxiety symptoms and poorer quality of life. Those with insomnia had a 2.4-fold increased risk for having not well-controlled asthma and a 1.5-fold increased risk for asthma-related health care utilization in the past year compared with those without insomnia.

Conclusions: Insomnia is highly prevalent in asthma and is associated with adverse outcomes. Further studies are needed to gain a better understanding of the interaction between insomnia and asthma control.

Keywords: asthma; depression; health care utilization; insomnia; quality of life.

Figures

Figure 1
Figure 1
Proportions of asthma-related health care utilization in the past 12 months in participants with asthmas and with or without insomnia (defined as score on the Insomnia Severity Index ≥ 10). *P < .01. **P < .001.
Figure 2
Figure 2
Proportions of asthma-related health care utilization in the past 12 months in participants with asthma and with or without comorbid insomnia (defined as score on the Insomnia Severity Index ≥ 10) by asthma control (defined by the Asthma Control Test: < 19 = controlled asthma; ≤ 19 = not well-controlled asthma).

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