Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 7 (3), 105-107

Polytherapy and Drug Interactions in Elderly

Affiliations
Review

Polytherapy and Drug Interactions in Elderly

Hima Bindu Gujjarlamudi. J Midlife Health.

Abstract

There is an increase in population of elderly above the age of 65. As age advances, more diseases develop resulting in use of more medications. Physiological changes, alterations in homeostatic regulation and diseases modify pharmacokinetics and drug response in older patients. The risk for drug interactions and drug-related problems increases along with multiple medications. Periodic evaluation of the patients' drug regimen is essential to minimize polytherapy. Clinicians must be alert to the use of herbal and dietary supplements as they are prone to drug-drug interactions. This article focuses on the possible pharmacokinetic, pharmacodynamic, and herbal drug interactions occurring in the elderly.

Keywords: Drug interactions; pharmacodynamics; pharmacokinetics; polytherapy.

Similar articles

See all similar articles

Cited by 2 PubMed Central articles

References

    1. New Delhi: Registrar General, India; 1996. Population Projections for India and States – 1996-2016. Census of India 1991 (Report)
    1. Ferner RE, Aronson JK. Communicating information about drug safety. BMJ. 2006;333:143–5. - PMC - PubMed
    1. Guaraldo L, Cano FG, Damasceno GS, Rozenfeld S. Inappropriate medication use among the elderly: A systematic review of administrative databases. BMC Geriatr. 2011;11:79. - PMC - PubMed
    1. Salazar JA, Poon I, Nair M. Clinical consequences of polypharmacy in elderly: Expect the unexpected, think the unthinkable. Expert Opin Drug Saf. 2007;6:695–704. - PubMed
    1. Shah BM, Hajjar ER. Polypharmacy, adverse drug reactions, and geriatric syndromes. Clin Geriatr Med. 2012;28:173–86. - PubMed
Feedback