Cerebral Erdheim-Chester Disease: Persistent Enhancement With Gd-DTPA on MR Images

Radiology. 1989 Sep;172(3):791-2. doi: 10.1148/radiology.172.3.2772189.

Abstract

A case of Erdheim-Chester disease with intracerebral masses containing characteristic lipid-laden histiocytes is presented. These unusual lesions remained enhanced on magnetic resonance images obtained 8 days after injection of gadolinium diethylenetriaminepentaacetic acid (DTPA) dimeglumine. Chemical analysis of a biopsy specimen revealed a high concentration of gadolinium. Findings suggest that the Gd-DTPA complex or possibly a gadolinium-containing metabolite may be retained for extended periods in this unusual type of histiocytic lesion.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Brain / pathology
  • Brain Diseases / diagnosis*
  • Contrast Media
  • Gadolinium
  • Gadolinium DTPA
  • Histiocytes / pathology
  • Humans
  • Magnetic Resonance Imaging*
  • Male
  • Middle Aged
  • Organometallic Compounds*
  • Pentetic Acid*
  • Time Factors
  • Xanthomatosis / diagnosis*

Substances

  • Contrast Media
  • Organometallic Compounds
  • Pentetic Acid
  • Gadolinium
  • Gadolinium DTPA