Near-infrared light-induced dissociation of zeolitic imidazole framework-8 (ZIF-8) with encapsulated CuS nanoparticles and their application as a therapeutic nanoplatform

Zhifei Wang; Xuejiao Tang; Xiaoxiao Wang; Dandan Yang; Chao Yang; Yongbing Lou; Jinxi Chen; Nongyue He

doi:10.1039/c6cc06616j

Near-infrared light-induced dissociation of zeolitic imidazole framework-8 (ZIF-8) with encapsulated CuS nanoparticles and their application as a therapeutic nanoplatform

Chem Commun (Camb). 2016 Oct 6;52(82):12210-12213. doi: 10.1039/c6cc06616j.

Authors

Zhifei Wang¹, Xuejiao Tang¹, Xiaoxiao Wang¹, Dandan Yang¹, Chao Yang¹, Yongbing Lou¹, Jinxi Chen¹, Nongyue He²

Affiliations

¹ School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, China. zfwang@seu.edu.cn jxchen@seu.edu.cn.
² School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China. nyhe@seu.edu.cn.

PMID: 27722473
DOI: 10.1039/c6cc06616j

Abstract

Incorporation of CuS nanoparticles into the framework of ZIF-8 provides a chance to integrate near-infrared (NIR) light/low pH triggered release and chemo-photothermal therapy into one system. For the first time, we observed that the framework of ZIF-8 could be disintegrated at pH 7.4 under NIR laser irradiation.