A new neonatal cortical and subcortical brain atlas: the Melbourne Children's Regional Infant Brain (M-CRIB) atlas

Bonnie Alexander; Andrea L Murray; Wai Yen Loh; Lillian G Matthews; Chris Adamson; Richard Beare; Jian Chen; Claire E Kelly; Sandra Rees; Simon K Warfield; Peter J Anderson; Lex W Doyle; Alicia J Spittle; Jeanie L Y Cheong; Marc L Seal; Deanne K Thompson

doi:10.1016/j.neuroimage.2016.09.068

A new neonatal cortical and subcortical brain atlas: the Melbourne Children's Regional Infant Brain (M-CRIB) atlas

Neuroimage. 2017 Feb 15:147:841-851. doi: 10.1016/j.neuroimage.2016.09.068. Epub 2016 Oct 8.

Authors

Affiliations

¹ Murdoch Childrens Research Institute, Melbourne, Victoria, Australia.
² Murdoch Childrens Research Institute, Melbourne, Victoria, Australia; Florey Institute of Neuroscience and Mental Health, Melbourne, Australia; The Florey Department of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Australia.
³ Murdoch Childrens Research Institute, Melbourne, Victoria, Australia; Department of Paediatrics, The University of Melbourne, Melbourne, Australia; Department of Newborn Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
⁴ Murdoch Childrens Research Institute, Melbourne, Victoria, Australia; Department of Medicine, Monash University, Melbourne, Australia.
⁵ Department of Anatomy and Neuroscience, University of Melbourne, Melbourne, Australia.
⁶ Department of Radiology, Children's Hospital, Harvard Medical School, Boston, MA, USA.
⁷ Murdoch Childrens Research Institute, Melbourne, Victoria, Australia; Department of Paediatrics, The University of Melbourne, Melbourne, Australia.
⁸ Murdoch Childrens Research Institute, Melbourne, Victoria, Australia; Department of Paediatrics, The University of Melbourne, Melbourne, Australia; Neonatal Services, The Royal Women's Hospital, Melbourne, Australia; Department of Obstetrics and Gynaecology, The University of Melbourne, Melbourne, Australia.
⁹ Murdoch Childrens Research Institute, Melbourne, Victoria, Australia; Neonatal Services, The Royal Women's Hospital, Melbourne, Australia; Department of Physiotherapy, The University of Melbourne, Melbourne, Australia.
¹⁰ Murdoch Childrens Research Institute, Melbourne, Victoria, Australia; Neonatal Services, The Royal Women's Hospital, Melbourne, Australia; Department of Obstetrics and Gynaecology, The University of Melbourne, Melbourne, Australia.
¹¹ Murdoch Childrens Research Institute, Melbourne, Victoria, Australia; Florey Institute of Neuroscience and Mental Health, Melbourne, Australia; Department of Paediatrics, The University of Melbourne, Melbourne, Australia. Electronic address: deanne.thompson@mcri.edu.au.

PMID: 27725314
DOI: 10.1016/j.neuroimage.2016.09.068

Abstract

Investigating neonatal brain structure and function can offer valuable insights into behaviour and cognition in healthy and clinical populations; both at term age, and longitudinally in comparison with later time points. Parcellated brain atlases for adult populations are readily available, however warping infant data to adult template space is not ideal due to morphological and tissue differences between these groups. Several parcellated neonatal atlases have been developed, although there remains strong demand for manually parcellated ground truth data with detailed cortical definition. Additionally, compatibility with existing adult atlases is favourable for use in longitudinal investigations. We aimed to address these needs by replicating the widely-used Desikan-Killiany (2006) adult cortical atlas in neonates. We also aimed to extend brain coverage by complementing this cortical scheme with basal ganglia, thalamus, cerebellum and other subcortical segmentations. Thus, we have manually parcellated these areas volumetrically using high-resolution neonatal T₂-weighted MRI scans, and initial automated and manually edited tissue classification, providing 100 regions in all. Linear and nonlinear T₂-weighted structural templates were also generated. In this paper we provide manual parcellation protocols, and present the parcellated probability maps and structural templates together as the Melbourne Children's Regional Infant Brain (M-CRIB) atlas.

Keywords: Ground truth; Infant; Manual parcellation; T(2)-weighted MRI; Template.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Atlases as Topic*
Brain / anatomy & histology*
Female
Humans
Infant, Newborn
Magnetic Resonance Imaging / methods*
Male