Prediction of Incident Diabetes in the Jackson Heart Study Using High-Dimensional Machine Learning

PLoS One. 2016 Oct 11;11(10):e0163942. doi: 10.1371/journal.pone.0163942. eCollection 2016.

Abstract

Statistical models to predict incident diabetes are often based on limited variables. Here we pursued two main goals: 1) investigate the relative performance of a machine learning method such as Random Forests (RF) for detecting incident diabetes in a high-dimensional setting defined by a large set of observational data, and 2) uncover potential predictors of diabetes. The Jackson Heart Study collected data at baseline and in two follow-up visits from 5,301 African Americans. We excluded those with baseline diabetes and no follow-up, leaving 3,633 individuals for analyses. Over a mean 8-year follow-up, 584 participants developed diabetes. The full RF model evaluated 93 variables including demographic, anthropometric, blood biomarker, medical history, and echocardiogram data. We also used RF metrics of variable importance to rank variables according to their contribution to diabetes prediction. We implemented other models based on logistic regression and RF where features were preselected. The RF full model performance was similar (AUC = 0.82) to those more parsimonious models. The top-ranked variables according to RF included hemoglobin A1C, fasting plasma glucose, waist circumference, adiponectin, c-reactive protein, triglycerides, leptin, left ventricular mass, high-density lipoprotein cholesterol, and aldosterone. This work shows the potential of RF for incident diabetes prediction while dealing with high-dimensional data.

MeSH terms

  • Adiponectin / blood
  • Adult
  • African Americans
  • Aged
  • Anthropometry
  • Biomarkers / blood
  • Blood Glucose / analysis
  • C-Reactive Protein / analysis
  • Cholesterol, HDL / blood
  • Demography
  • Diabetes Mellitus, Type 2 / epidemiology*
  • Female
  • Follow-Up Studies
  • Glycated Hemoglobin A / analysis
  • Humans
  • Incidence
  • Leptin / blood
  • Machine Learning*
  • Male
  • Middle Aged
  • Models, Theoretical
  • Triglycerides / blood
  • Waist Circumference

Substances

  • Adiponectin
  • Biomarkers
  • Blood Glucose
  • Cholesterol, HDL
  • Glycated Hemoglobin A
  • Leptin
  • Triglycerides
  • C-Reactive Protein