Advanced glycation end-products are a risk for muscle weakness in Japanese patients with type 1 diabetes

J Diabetes Investig. 2017 May;8(3):377-382. doi: 10.1111/jdi.12582. Epub 2016 Nov 23.


Accumulation of advanced glycation end-products (AGEs) is thought to contribute to muscle weakness in a diabetic animal model. Skin autofluorescence is a proposed marker for accumulation of AGEs in the skin. We aimed to investigate the relationship between AGEs accumulation, sarcopenia and muscle function of Japanese patients with type 1 diabetes. A total of 36 patients with type 1 diabetes participated in the present cross-sectional study. Sarcopenia parameters (skeletal muscle mass index and knee extension strength) were compared with subcutaneous AGEs accumulation using skin autofluorescence. The prevalence of sarcopenia and impaired knee extension strength was 16.6% (men 0.0%, women 22.2%) and 47.2% (men 22.2%, women 55.6%), respectively. Knee extension strength was negatively correlated with skin autofluorescence (r² = 0.14, P < 0.05), but not with skeletal muscle mass index. In conclusion, the AGEs accumulation might be one of the reasons of impaired lower limb muscle function in Japanese patients with type 1 diabetes.

Keywords: Advanced glycation end-products; Sarcopenia; Type 1 diabetes.

MeSH terms

  • Asians
  • Cross-Sectional Studies
  • Diabetes Mellitus, Type 1 / complications*
  • Diabetes Mellitus, Type 1 / epidemiology
  • Female
  • Glycation End Products, Advanced / metabolism*
  • Humans
  • Japan
  • Male
  • Middle Aged
  • Muscle Weakness / complications*
  • Muscle Weakness / epidemiology
  • Muscle Weakness / metabolism*
  • Risk Factors
  • Sarcopenia / complications*
  • Sarcopenia / epidemiology
  • Sarcopenia / metabolism*


  • Glycation End Products, Advanced