Senescence and Cancer: In the Name of Immunosuppression

Susana Llanos; Manuel Serrano

doi:10.1016/j.ccell.2016.09.015

Senescence and Cancer: In the Name of Immunosuppression

Cancer Cell. 2016 Oct 10;30(4):507-508. doi: 10.1016/j.ccell.2016.09.015.

Authors

Susana Llanos¹, Manuel Serrano²

Affiliations

¹ Spanish National Cancer Research Centre (CNIO), Madrid 28029, Spain. Electronic address: sllanos@cnio.es.
² Spanish National Cancer Research Centre (CNIO), Madrid 28029, Spain. Electronic address: mserrano@cnio.es.

PMID: 27728798
DOI: 10.1016/j.ccell.2016.09.015

Abstract

Senescent cells and cancer cells recruit immunosuppressive myeloid cells. In this issue of Cancer Cell, Eggert et al. report that senescent cells recruit immature myeloid cells (iMCs) through the secretion of the CCL2 cytokine and that these iMCs have pro- or anti-tumorigenic activities, depending on the cellular context.

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MeSH terms

Cellular Senescence
Cytokines
Humans
Immune Tolerance*
Myeloid Cells
Neoplasms*

Substances

Cytokines