Serous tubal intraepithelial carcinoma (STIC) - clinical impact and management

Expert Rev Anticancer Ther. 2016 Dec;16(12):1311-1321. doi: 10.1080/14737140.2016.1247699. Epub 2016 Oct 22.


Serous tubal intraepithelial carcinoma (STIC) is most likely precursor lesion of the most part of high-grade serous pelvis carcinomas, carcinosarcoma and undifferentiated carcinoma with incidence of 0.6% to 7% in BRCA carriers or women with strong family history of breast or ovarian carcinoma. STIC is a pathomorphologically and immunohistochemically detectable lesion which biological significance and clinical relevance is unknown. Areas covered: We investigate methods of STIC diagnostics and we present an overview of recent studies and available knowledge on surgical management, adjuvant chemotherapy and subsequent follow-up procedure in women with an isolated STIC. Expert commentary: Patients found to have an incidental STIC lesion should be referred for screening of BRCA1/2 mutation. In absence of an invasive disease, follow-up of patient remains a reasonable choice. A rational scheme should include check-ups every 6 months consisting of gynecological examinations, CA 125 and/or HE4 and pelvic ultrasound examination by an expert sonographer.

Keywords: BRCA mutation; fallopian tube; ovarian carcinoma; risk reducingsalpingo-oophorectomy; serous tubal intraepithelial carcinoma.

Publication types

  • Review

MeSH terms

  • Animals
  • BRCA1 Protein / genetics
  • BRCA2 Protein / genetics
  • Carcinoma in Situ / diagnosis
  • Carcinoma in Situ / pathology
  • Carcinoma in Situ / therapy*
  • Chemotherapy, Adjuvant / methods
  • Fallopian Tube Neoplasms / diagnosis
  • Fallopian Tube Neoplasms / pathology
  • Fallopian Tube Neoplasms / therapy*
  • Female
  • Humans
  • Immunohistochemistry
  • Incidence
  • Mutation
  • Neoplasms, Cystic, Mucinous, and Serous / diagnosis
  • Neoplasms, Cystic, Mucinous, and Serous / pathology
  • Neoplasms, Cystic, Mucinous, and Serous / therapy*


  • BRCA1 Protein
  • BRCA1 protein, human
  • BRCA2 Protein
  • BRCA2 protein, human