Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 Jan 14;68:85-98.
doi: 10.1146/annurev-med-051215-031109. Epub 2016 Oct 5.

Nonalcoholic Steatohepatitis

Affiliations
Review

Nonalcoholic Steatohepatitis

Ayako Suzuki et al. Annu Rev Med. .

Abstract

Nonalcoholic steatohepatitis (NASH) has become a major cause of cirrhosis and liver-related deaths worldwide. NASH is strongly associated with obesity and the metabolic syndrome, conditions that cause lipid accumulation in hepatocytes (hepatic steatosis). It is not well understood why some, but not other, individuals with hepatic steatosis develop NASH. The factors that determine whether or not NASH progresses to cirrhosis are also unclear. This review summarizes key components of NASH pathogenesis and discusses how inherent and acquired variations in regulation of these processes impact the risk for NASH and NASH cirrhosis.

Keywords: adaptive mechanisms; hepatic fibrosis; hepatocyte damage; lipotoxicity; nonalcoholic fatty liver disease.

Similar articles

See all similar articles

Cited by 20 articles

See all "Cited by" articles

LinkOut - more resources

Feedback