Danio rerio ABC transporter genes abcb3 and abcb7 play a protecting role against metal contamination

J Appl Toxicol. 2016 Dec;36(12):1551-1557. doi: 10.1002/jat.3313. Epub 2016 Mar 28.


ATP-binding cassette (ABC) proteins are efflux transporters and some of them are involved in xenobiotic detoxification. The involvement of four zebrafish ABC transporters in cadmium, zinc and mercury detoxification was characterized in a metal hypersensitive mutant of Escherichia coli. The E. coli tolC mutant expressing ABCB3 or ABCB7 transporters exhibited higher survival ratios and lower metal accumulation under a metal exposure condition than the controls. For instance, in the presence of 8 and 10 μM of HgCl2 , the survival ratios of bacteria expressing ABCB3 were four and six-times higher than the control whereas the mercury concentrations were 2.5 and 2-times lower than in the control. This work provides new data on the function of zebrafish ABCB3 and ABCB7 transporters and highlights their significance in metal detoxification. Copyright © 2016 John Wiley & Sons, Ltd.

Keywords: ABC transporters; metals; mitochondrial transporter; protection; zebrafish.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • ATP-Binding Cassette Transporters / genetics*
  • Animals
  • Dose-Response Relationship, Drug
  • Escherichia coli / genetics
  • Gene Expression / drug effects
  • Metals, Heavy / metabolism
  • Metals, Heavy / toxicity*
  • Microbial Viability / drug effects
  • Mutation
  • Water Pollutants, Chemical / metabolism
  • Water Pollutants, Chemical / toxicity*
  • Zebrafish / genetics*
  • Zebrafish Proteins / genetics*


  • ATP-Binding Cassette Transporters
  • Metals, Heavy
  • Water Pollutants, Chemical
  • Zebrafish Proteins
  • tap2t protein, zebrafish